Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2358924..2359562 Replicon chromosome
Accession NZ_LR134315
Organism Escherichia coli strain NCTC9064

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag EL184_RS11525 Protein ID WP_000813794.1
Coordinates 2359386..2359562 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL184_RS11520 Protein ID WP_001270286.1
Coordinates 2358924..2359340 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL184_RS11500 2354076..2355017 - 942 WP_096835667.1 ABC transporter permease -
EL184_RS11505 2355018..2356031 - 1014 WP_096835666.1 ABC transporter ATP-binding protein -
EL184_RS11510 2356049..2357194 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
EL184_RS11515 2357439..2358845 - 1407 WP_000760614.1 PLP-dependent aminotransferase family protein -
EL184_RS11520 2358924..2359340 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EL184_RS11525 2359386..2359562 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EL184_RS11530 2359784..2360014 + 231 WP_000494244.1 YncJ family protein -
EL184_RS11535 2360106..2362067 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EL184_RS11540 2362140..2362676 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
EL184_RS11545 2362729..2363943 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2363983..2365131 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T287649 WP_000813794.1 NZ_LR134315:c2359562-2359386 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT287649 WP_001270286.1 NZ_LR134315:c2359340-2358924 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References