Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2199877..2200403 Replicon chromosome
Accession NZ_LR134315
Organism Escherichia coli strain NCTC9064

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL184_RS10765 Protein ID WP_000323025.1
Coordinates 2200116..2200403 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL184_RS10760 Protein ID WP_000534858.1
Coordinates 2199877..2200116 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL184_RS10730 2196274..2196579 - 306 WP_001295396.1 DUF1161 domain-containing protein -
EL184_RS10735 2196687..2197397 + 711 WP_001321287.1 YnfC family lipoprotein -
EL184_RS10740 2197400..2197960 - 561 WP_001138581.1 spermidine N1-acetyltransferase -
EL184_RS10745 2197995..2198336 - 342 WP_000705197.1 DUF1283 family protein -
EL184_RS10755 2199646..2199852 - 207 Protein_2075 hypothetical protein -
EL184_RS10760 2199877..2200116 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL184_RS10765 2200116..2200403 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL184_RS10770 2200475..2200630 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL184_RS10775 2200847..2201098 + 252 WP_000980991.1 hypothetical protein -
EL184_RS10780 2201165..2201443 + 279 WP_001309521.1 hypothetical protein -
EL184_RS10785 2201445..2202494 + 1050 WP_087892834.1 DUF968 domain-containing protein -
EL184_RS10790 2202508..2203260 + 753 WP_001047133.1 antitermination protein -
EL184_RS10795 2203435..2203637 - 203 Protein_2083 cold shock-like protein CspF -
EL184_RS10800 2203936..2204151 + 216 WP_000066484.1 cold shock-like protein CspB -
EL184_RS22805 2204515..2204685 - 171 WP_001405948.1 putative zinc-binding protein YnfU -
EL184_RS10805 2204905..2205120 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2189681..2220879 31198
- inside Prophage - - 2184552..2227778 43226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287647 WP_000323025.1 NZ_LR134315:2200116-2200403 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287647 WP_000534858.1 NZ_LR134315:2199877-2200116 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References