Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1286238..1286863 Replicon chromosome
Accession NZ_LR134315
Organism Escherichia coli strain NCTC9064

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL184_RS06280 Protein ID WP_000911330.1
Coordinates 1286465..1286863 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag EL184_RS06275 Protein ID WP_000450524.1
Coordinates 1286238..1286465 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL184_RS06250 1282041..1282511 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
EL184_RS06255 1282511..1283083 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
EL184_RS06260 1283229..1284107 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
EL184_RS06265 1284124..1285158 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
EL184_RS06270 1285371..1286084 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EL184_RS06275 1286238..1286465 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
EL184_RS06280 1286465..1286863 + 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
EL184_RS06285 1287010..1287873 + 864 WP_001267498.1 neutral zinc metallopeptidase -
EL184_RS06290 1287888..1289903 + 2016 WP_096835357.1 tRNA cytosine(34) acetyltransferase TmcA -
EL184_RS06295 1289977..1290675 + 699 WP_000679808.1 esterase -
EL184_RS06300 1290785..1290985 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T287641 WP_000911330.1 NZ_LR134315:1286465-1286863 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT287641 WP_000450524.1 NZ_LR134315:1286238-1286465 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References