28764

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2410092..2410621 Replicon chromosome
Accession NC_020089
Organism Mycobacterium tuberculosis 7199-99

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag MT7199_RS11230 Protein ID WP_003411124.1
Coordinates 2410092..2410409 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag MT7199_RS11235 Protein ID WP_003411127.1
Coordinates 2410406..2410621 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT7199_RS11200 2405113..2406189 + 1077 WP_003411110.1 hypothetical protein -
MT7199_RS11205 2406186..2406467 + 282 WP_003411112.1 hypothetical protein -
MT7199_RS11210 2406503..2407576 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
MT7199_RS11215 2407581..2408111 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
MT7199_RS11220 2408159..2409505 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
MT7199_RS11230 2410092..2410409 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MT7199_RS11235 2410406..2410621 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
MT7199_RS11240 2410876..2411934 + 1059 WP_003411129.1 hypothetical protein -
MT7199_RS11245 2412064..2412420 - 357 WP_003411130.1 hypothetical protein -
MT7199_RS11250 2412515..2413297 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
MT7199_RS11255 2413565..2413855 - 291 WP_003900476.1 YggT family protein -
MT7199_RS11260 2414017..2414673 - 657 WP_015456354.1 cell division protein SepF -
MT7199_RS11265 2414739..2415515 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T28764 WP_003411124.1 NC_020089:c2410409-2410092 [Mycobacterium tuberculosis 7199-99]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T28764 NC_020089:c2410409-2410092 [Mycobacterium tuberculosis 7199-99]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT28764 WP_003411127.1 NC_020089:c2410621-2410406 [Mycobacterium tuberculosis 7199-99]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT28764 NC_020089:c2410621-2410406 [Mycobacterium tuberculosis 7199-99]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References