Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876555..877215 Replicon chromosome
Accession NZ_LR134315
Organism Escherichia coli strain NCTC9064

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag EL184_RS04290 Protein ID WP_096835313.1
Coordinates 876802..877215 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag EL184_RS04285 Protein ID WP_000354046.1
Coordinates 876555..876821 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL184_RS04260 871843..872586 + 744 WP_000951948.1 SDR family oxidoreductase -
EL184_RS04265 872643..874076 - 1434 WP_001343615.1 6-phospho-beta-glucosidase BglA -
EL184_RS04270 874121..874432 + 312 WP_001182947.1 N(4)-acetylcytidine aminohydrolase -
EL184_RS04275 874596..875255 + 660 WP_096835312.1 hemolysin III family protein -
EL184_RS04280 875332..876312 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
EL184_RS04285 876555..876821 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
EL184_RS04290 876802..877215 + 414 WP_096835313.1 protein YgfX Toxin
EL184_RS04295 877249..877770 - 522 WP_001055874.1 flavodoxin FldB -
EL184_RS04300 877882..878778 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
EL184_RS04305 878802..879512 + 711 WP_000715231.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EL184_RS04310 879518..881251 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16245.14 Da        Isoelectric Point: 11.7064

>T287638 WP_096835313.1 NZ_LR134315:876802-877215 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLTDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQRSR

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT287638 WP_000354046.1 NZ_LR134315:876555-876821 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References