Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 679495..680218 Replicon chromosome
Accession NZ_LR134315
Organism Escherichia coli strain NCTC9064

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag EL184_RS03325 Protein ID WP_063941845.1
Coordinates 679898..680218 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag EL184_RS03320 Protein ID WP_096835290.1
Coordinates 679495..679830 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL184_RS03295 675010..675447 + 438 WP_096835285.1 hypothetical protein -
EL184_RS03300 675510..675908 + 399 WP_096835286.1 hypothetical protein -
EL184_RS03305 676354..677532 - 1179 WP_096835287.1 hypothetical protein -
EL184_RS03310 677639..678364 - 726 WP_157912351.1 hypothetical protein -
EL184_RS03315 679002..679481 + 480 WP_096835289.1 DNA repair protein RadC -
EL184_RS03320 679495..679830 + 336 WP_096835290.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL184_RS03325 679898..680218 + 321 WP_063941845.1 TA system toxin CbtA family protein Toxin
EL184_RS03330 680332..681165 + 834 WP_096835291.1 DUF4942 domain-containing protein -
EL184_RS03340 681468..681974 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
EL184_RS03345 682053..683894 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(8-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12095.73 Da        Isoelectric Point: 5.5094

>T287637 WP_063941845.1 NZ_LR134315:679898-680218 [Escherichia coli]
MQISTVPATLPVSSRLSPVQVWQQLLTYLLEQHYGLTLNDTPFHDDSAIHEHIEAGITLADAVNFLVERYELIRTDRKGF
TWQEQTPFLTATDILRARRATGLMNT

Download         Length: 321 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12344.10 Da        Isoelectric Point: 6.3143

>AT287637 WP_096835290.1 NZ_LR134315:679495-679830 [Escherichia coli]
MNKDAPQIWGLKRDITPCFGARLVQEGNRLHFLADRAGFTGSFSEMLALQLDEAFAHFVAHLELMLLSGELNPRCAHCAT
LYRNGLTCEADTLGSHGYVYIAIYPSNQVKD

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References