Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 263653..264251 Replicon chromosome
Accession NZ_LR134315
Organism Escherichia coli strain NCTC9064

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL184_RS01200 Protein ID WP_096835382.1
Coordinates 263653..263895 (+) Length 81 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag EL184_RS01205 Protein ID WP_000593555.1
Coordinates 263892..264251 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL184_RS01185 261198..262322 + 1125 WP_001216257.1 ABC transporter permease -
EL184_RS01190 262395..262466 + 72 Protein_229 hexulose-6-phosphate synthase -
EL184_RS01195 262536..263656 + 1121 WP_087451024.1 IS3-like element ISSen4 family transposase -
EL184_RS01200 263653..263895 + 243 WP_096835382.1 type II toxin-antitoxin system HicA family toxin Toxin
EL184_RS01205 263892..264251 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL184_RS01210 264371..264772 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
EL184_RS01215 264778..265584 - 807 WP_000173673.1 nickel import ATP-binding protein NikE -
EL184_RS01220 265581..266345 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
EL184_RS01225 266345..267178 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
EL184_RS01230 267175..268119 - 945 WP_096835383.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(19-69)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 8673.01 Da        Isoelectric Point: 10.1142

>T287634 WP_096835382.1 NZ_LR134315:263653-263895 [Escherichia coli]
MSVVSNRGGRSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 243 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT287634 WP_000593555.1 NZ_LR134315:263892-264251 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References