287633

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1066818..1067430 Replicon chromosome
Accession NZ_LR134314
Organism Streptococcus pyogenes strain NCTC8302

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag EL107_RS05450 Protein ID WP_011018227.1
Coordinates 1067095..1067430 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag EL107_RS05445 Protein ID WP_002988079.1
Coordinates 1066818..1067105 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL107_RS05420 1062009..1062992 - 984 WP_011184964.1 tagatose-bisphosphate aldolase -
EL107_RS05425 1062996..1063925 - 930 WP_011184965.1 tagatose-6-phosphate kinase -
EL107_RS05430 1063971..1064486 - 516 WP_011184966.1 galactose-6-phosphate isomerase subunit LacB -
EL107_RS05435 1064521..1064949 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
EL107_RS05440 1065395..1066168 + 774 WP_011184967.1 DeoR/GlpR family DNA-binding transcription regulator -
EL107_RS05445 1066818..1067105 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
EL107_RS05450 1067095..1067430 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL107_RS09485 1067528..1068566 + 1039 Protein_1035 site-specific integrase -
EL107_RS05475 1068698..1069090 - 393 WP_002982716.1 30S ribosomal protein S9 -
EL107_RS05480 1069111..1069557 - 447 WP_011018228.1 50S ribosomal protein L13 -
EL107_RS05485 1069775..1069981 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
EL107_RS05490 1069978..1070676 - 699 WP_021340263.1 hypothetical protein -
EL107_RS05495 1070812..1071672 - 861 WP_002982687.1 DegV family protein -
EL107_RS05500 1071769..1072287 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T287633 WP_011018227.1 NZ_LR134314:1067095-1067430 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT287633 WP_002988079.1 NZ_LR134314:1066818-1067105 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References