Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1850308..1851056 Replicon chromosome
Accession NZ_LR134313
Organism Neisseria canis strain NCTC10296

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag EL143_RS08760 Protein ID WP_085415883.1
Coordinates 1850308..1850784 (-) Length 159 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag EL143_RS08765 Protein ID WP_197719588.1
Coordinates 1850790..1851056 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL143_RS08725 1845767..1846990 + 1224 WP_085415788.1 TraB/VirB10 family protein -
EL143_RS08730 1846987..1847622 + 636 WP_085415789.1 TraV family lipoprotein -
EL143_RS08735 1847642..1847998 + 357 WP_085415790.1 hypothetical protein -
EL143_RS08740 1848007..1848453 + 447 WP_126326712.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
EL143_RS08745 1848609..1849022 + 414 WP_085415791.1 hypothetical protein -
EL143_RS08750 1849038..1849610 + 573 WP_085415882.1 DUF882 domain-containing protein -
EL143_RS08755 1849640..1850284 + 645 WP_085415792.1 hypothetical protein -
EL143_RS08760 1850308..1850784 - 477 WP_085415883.1 GNAT family N-acetyltransferase Toxin
EL143_RS08765 1850790..1851056 - 267 WP_197719588.1 DUF1778 domain-containing protein Antitoxin
EL143_RS08770 1851297..1852007 + 711 WP_085415793.1 recombinase family protein -
EL143_RS08775 1852143..1853579 + 1437 WP_085415794.1 ParB/Srx family N-terminal domain-containing protein -
EL143_RS08780 1853661..1854524 + 864 WP_085415795.1 DNA adenine methylase -
EL143_RS08785 1854609..1855070 + 462 WP_085415796.1 virulence factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(25-147)

Antitoxin

Vibrio phage ICP1, Orf50

(3-87)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 17616.45 Da        Isoelectric Point: 9.0663

>T287631 WP_085415883.1 NZ_LR134313:c1850784-1850308 [Neisseria canis]
MEKLTAPQLLSEMHVIDGFDCGIASLNEWLVKNALKNQYSNASRTFVVCDQEQTVLGYYCLAAGSLTHEEAIGAIRRNMP
SPIPIIVLGRLAVDFRAQGKELGKSLLRDAVLRSQNISQQLGARALLVHAISEEAKRFYLKYGFKSSELSPYTLMRKL

Download         Length: 477 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10059.59 Da        Isoelectric Point: 5.1104

>AT287631 WP_197719588.1 NZ_LR134313:c1851056-1850790 [Neisseria canis]
MLKTAPINLRALESQKKLIDQAAALSGKTRSEFILEASCSAAENTLLEKTFFILPIDKYKQFINLLEQPTDNNEGFERLM
QTTPVWER

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References