Detailed information of TA system TA287606

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 3727421..3728112
• Replicon: chromosome
• Accession: NZ_LR134311
• Organism: Escherichia coli strain NCTC9113

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A2A3UTQ9
• Locus tag: EL186_RS18120
• Protein ID: WP_001094399.1
• Coordinates: 3727421..3727789 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: EL186_RS18125
• Protein ID: WP_001405555.1
• Coordinates: 3727810..3728112 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL186_RS18100	3722593..3723549	+	957	WP_000643333.1	aldehyde oxidoreductase FAD-binding subunit PaoB	-
EL186_RS18105	3723546..3725744	+	2199	WP_000667065.1	aldehyde oxidoreductase molybdenum-binding subunit PaoC	-
EL186_RS18110	3725755..3726711	+	957	WP_000121356.1	molybdenum cofactor insertion chaperone PaoD	-
EL186_RS18115	3726762..3727100	+	339	Protein_3495	LysR family transcriptional regulator	-
EL186_RS18120	3727421..3727789	-	369	WP_001094399.1	TA system toxin CbtA family protein	Toxin
EL186_RS18125	3727810..3728112	-	303	WP_001405555.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
EL186_RS18130	3728219..3728863	-	645	WP_000086755.1	hypothetical protein	-
EL186_RS18135	3728882..3729103	-	222	WP_000692307.1	DUF987 domain-containing protein	-
EL186_RS18140	3729172..3729648	-	477	WP_001573263.1	RadC family protein	-
EL186_RS18145	3729664..3730137	-	474	WP_000855084.1	antirestriction protein	-
EL186_RS18150	3730275..3730475	-	201	WP_001420888.1	hypothetical protein	-
EL186_RS18155	3730475..3731296	-	822	WP_001761104.1	DUF945 domain-containing protein	-
EL186_RS18165	3731397..3731605	-	209	Protein_3504	DUF905 domain-containing protein	-
EL186_RS18170	3731706..3732161	-	456	WP_126352615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3690853..3771277	80424

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (2-99)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13568.73 Da
• Isoelectric Point: 7.7465

>T287606 WP_001094399.1 NZ_LR134311:c3727789-3727421 [Escherichia coli]
MNTLPATISPAAKPCPSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRNGF
TSQVQAPYLTATDILQARKACGLMSRCSYRDVSNIVLSRSRL

Nucleotide

• Length: 369 bp

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11132.66 Da
• Isoelectric Point: 6.0454

>AT287606 WP_001405555.1 NZ_LR134311:c3728112-3727810 [Escherichia coli]
VGLPYTVTPCSGTRLVQEGNRLYYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCFTLYHNGFTC
EADTLGSCGYVYIAIYPTQL

Nucleotide

• Length: 303 bp

Structures

Toxin

• AlphaFold DB: A0A2A3UTQ9