Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | itaRT/DUF1778(antitoxin) |
Location | 3561686..3562523 | Replicon | chromosome |
Accession | NZ_LR134311 | ||
Organism | Escherichia coli strain NCTC9113 |
Toxin (Protein)
Gene name | itaT | Uniprot ID | Q3Z4X7 |
Locus tag | EL186_RS17370 | Protein ID | WP_000227784.1 |
Coordinates | 3561981..3562523 (+) | Length | 181 a.a. |
Antitoxin (Protein)
Gene name | itaR | Uniprot ID | I2UQS9 |
Locus tag | EL186_RS17365 | Protein ID | WP_001297137.1 |
Coordinates | 3561686..3561997 (+) | Length | 104 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EL186_RS17340 | 3556706..3557653 | + | 948 | WP_001239441.1 | cytochrome o ubiquinol oxidase subunit II | - |
EL186_RS17345 | 3557675..3559666 | + | 1992 | WP_000467180.1 | cytochrome o ubiquinol oxidase subunit I | - |
EL186_RS17350 | 3559656..3560270 | + | 615 | WP_000179819.1 | cytochrome o ubiquinol oxidase subunit III | - |
EL186_RS17355 | 3560270..3560599 | + | 330 | WP_000019869.1 | cytochrome o ubiquinol oxidase subunit IV | - |
EL186_RS17360 | 3560611..3561501 | + | 891 | WP_000971336.1 | heme o synthase | - |
EL186_RS17365 | 3561686..3561997 | + | 312 | WP_001297137.1 | DUF1778 domain-containing protein | Antitoxin |
EL186_RS17370 | 3561981..3562523 | + | 543 | WP_000227784.1 | GNAT family N-acetyltransferase | Toxin |
EL186_RS17375 | 3562579..3563514 | - | 936 | WP_001297127.1 | sel1 repeat family protein | - |
EL186_RS17380 | 3563922..3565286 | + | 1365 | WP_001000978.1 | MFS transporter | - |
EL186_RS17385 | 3565414..3565905 | - | 492 | WP_001138904.1 | nucleotide binding protein YajQ | - |
EL186_RS17390 | 3566073..3566984 | + | 912 | WP_000705853.1 | 2-dehydropantoate 2-reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 181 a.a. Molecular weight: 19805.02 Da Isoelectric Point: 8.3395
>T287605 WP_000227784.1 NZ_LR134311:3561981-3562523 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA
Download Length: 543 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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