Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3527597..3528215 Replicon chromosome
Accession NZ_LR134311
Organism Escherichia coli strain NCTC9113

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EL186_RS17200 Protein ID WP_001291435.1
Coordinates 3527997..3528215 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EL186_RS17195 Protein ID WP_000344800.1
Coordinates 3527597..3527971 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL186_RS17185 3522686..3523879 + 1194 WP_044862765.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL186_RS17190 3523902..3527051 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
EL186_RS17195 3527597..3527971 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EL186_RS17200 3527997..3528215 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EL186_RS17205 3528387..3528938 + 552 WP_000102568.1 maltose O-acetyltransferase -
EL186_RS17210 3529054..3529524 + 471 WP_000136192.1 YlaC family protein -
EL186_RS17215 3529688..3531238 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EL186_RS17220 3531280..3531633 - 354 WP_000878140.1 DUF1428 domain-containing protein -
EL186_RS17230 3532012..3532323 + 312 WP_000409911.1 MGMT family protein -
EL186_RS17235 3532354..3532926 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T287604 WP_001291435.1 NZ_LR134311:3527997-3528215 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT287604 WP_000344800.1 NZ_LR134311:3527597-3527971 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References