287597

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1424863..1425488 Replicon chromosome
Accession NZ_LR134311
Organism Escherichia coli strain NCTC9113

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL186_RS06985 Protein ID WP_000911330.1
Coordinates 1425090..1425488 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag EL186_RS06980 Protein ID WP_000450524.1
Coordinates 1424863..1425090 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL186_RS06955 1420666..1421136 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
EL186_RS06960 1421136..1421708 - 573 WP_000176191.1 glycine cleavage system transcriptional repressor -
EL186_RS06965 1421854..1422732 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
EL186_RS06970 1422749..1423783 + 1035 WP_001358397.1 outer membrane protein assembly factor BamC -
EL186_RS06975 1423996..1424709 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EL186_RS06980 1424863..1425090 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
EL186_RS06985 1425090..1425488 + 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
EL186_RS06990 1425635..1426498 + 864 WP_001267508.1 neutral zinc metallopeptidase -
EL186_RS06995 1426513..1428528 + 2016 WP_044862802.1 tRNA cytosine(34) acetyltransferase TmcA -
EL186_RS07000 1428602..1429300 + 699 WP_000679823.1 esterase -
EL186_RS07005 1429410..1429610 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T287597 WP_000911330.1 NZ_LR134311:1425090-1425488 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT287597 WP_000450524.1 NZ_LR134311:1424863-1425090 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References