287595

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 989824..990478 Replicon chromosome
Accession NZ_LR134311
Organism Escherichia coli strain NCTC9113

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag EL186_RS04890 Protein ID WP_000244772.1
Coordinates 990071..990478 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag EL186_RS04885 Protein ID WP_000354046.1
Coordinates 989824..990090 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL186_RS04860 985112..985855 + 744 WP_000951964.1 SDR family oxidoreductase -
EL186_RS04865 985912..987345 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
EL186_RS04870 987390..987701 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
EL186_RS04875 987865..988524 + 660 WP_000250274.1 hemolysin III family protein -
EL186_RS04880 988601..989581 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
EL186_RS04885 989824..990090 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
EL186_RS04890 990071..990478 + 408 WP_000244772.1 protein YgfX Toxin
EL186_RS04895 990518..991039 - 522 WP_001055874.1 flavodoxin FldB -
EL186_RS04900 991151..992047 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
EL186_RS04905 992072..992782 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EL186_RS04910 992788..994521 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T287595 WP_000244772.1 NZ_LR134311:990071-990478 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT287595 WP_000354046.1 NZ_LR134311:989824-990090 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References