287591

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 1556681..1557323 Replicon chromosome
Accession NZ_LR134310
Organism Actinobacillus equuli strain NCTC8529

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag EL121_RS07385 Protein ID WP_005621659.1
Coordinates 1556681..1557052 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag EL121_RS07390 Protein ID WP_039198813.1
Coordinates 1557033..1557323 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL121_RS07370 1553188..1554042 + 855 WP_039198806.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
EL121_RS07375 1554086..1554655 - 570 WP_039198809.1 elongation factor P hydroxylase -
EL121_RS07380 1554715..1556463 - 1749 WP_039198811.1 protein-disulfide reductase DsbD -
EL121_RS07385 1556681..1557052 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL121_RS07390 1557033..1557323 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
EL121_RS07395 1557391..1558353 - 963 WP_039198815.1 calcium/sodium antiporter -
EL121_RS07400 1558426..1558923 + 498 WP_039198817.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
EL121_RS07405 1559148..1559882 + 735 WP_039198820.1 arginine ABC transporter ATP-binding protein ArtP -
EL121_RS07410 1559887..1560621 + 735 WP_197050930.1 transporter substrate-binding domain-containing protein -
EL121_RS07415 1560627..1561298 + 672 WP_039198825.1 arginine ABC transporter permease ArtQ -
EL121_RS07420 1561298..1561981 + 684 WP_039198827.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T287591 WP_005621659.1 NZ_LR134310:1556681-1557052 [Actinobacillus equuli]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT287591 WP_039198813.1 NZ_LR134310:1557033-1557323 [Actinobacillus equuli]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References