287588

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5141103..5141711 Replicon chromosome
Accession NZ_LR134309
Organism Pseudomonas aeruginosa strain NCTC12903

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag EL344_RS24970 Protein ID WP_003123043.1
Coordinates 5141103..5141450 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag EL344_RS24975 Protein ID WP_003114155.1
Coordinates 5141460..5141711 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL344_RS24945 5137379..5138611 + 1233 WP_016852057.1 phosphoadenosine phosphosulfate reductase family protein -
EL344_RS33315 5138622..5138798 + 177 WP_016852058.1 hypothetical protein -
EL344_RS24950 5138795..5139163 + 369 WP_016852059.1 ASCH domain-containing protein -
EL344_RS24960 5139356..5139559 + 204 WP_003098423.1 AlpA family phage regulatory protein -
EL344_RS24965 5139566..5140768 - 1203 WP_016852061.1 integrase family protein -
EL344_RS24970 5141103..5141450 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL344_RS24975 5141460..5141711 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL344_RS24980 5141925..5142908 - 984 WP_016852062.1 tyrosine-type recombinase/integrase -
EL344_RS24985 5142908..5144200 - 1293 WP_003115206.1 hypothetical protein -
EL344_RS24990 5144459..5145721 - 1263 WP_023093179.1 hypothetical protein -
EL344_RS24995 5145723..5146073 - 351 WP_003159569.1 DUF2523 domain-containing protein -
EL344_RS25000 5146083..5146688 - 606 WP_014603242.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5017571..5153034 135463


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T287588 WP_003123043.1 NZ_LR134309:c5141450-5141103 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT287588 WP_003114155.1 NZ_LR134309:c5141711-5141460 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References