Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4657422..4658680 Replicon chromosome
Accession NZ_LR134309
Organism Pseudomonas aeruginosa strain NCTC12903

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag EL344_RS22565 Protein ID WP_003112528.1
Coordinates 4657422..4658177 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag EL344_RS22570 Protein ID WP_003086329.1
Coordinates 4658312..4658680 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL344_RS22555 4652595..4655138 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
EL344_RS22560 4655293..4656654 - 1362 WP_073647918.1 DNA recombination protein RmuC -
EL344_RS22565 4657422..4658177 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
EL344_RS22570 4658312..4658680 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
EL344_RS22575 4658753..4660039 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
EL344_RS22580 4660095..4661684 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
EL344_RS22585 4661763..4662239 + 477 WP_003112531.1 hypothetical protein -
EL344_RS33265 4662242..4662517 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T287587 WP_003112528.1 NZ_LR134309:c4658177-4657422 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT287587 WP_003086329.1 NZ_LR134309:c4658680-4658312 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References