287586

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3684646..3685867 Replicon chromosome
Accession NZ_LR134309
Organism Pseudomonas aeruginosa strain NCTC12903

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL344_RS17845 Protein ID WP_003114949.1
Coordinates 3685289..3685867 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL344_RS17840 Protein ID WP_003088112.1
Coordinates 3684646..3685200 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL344_RS17815 3680214..3680765 + 552 WP_003102727.1 XRE family transcriptional regulator -
EL344_RS17820 3680762..3681160 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
EL344_RS17825 3681173..3681496 - 324 WP_003102734.1 multidrug efflux SMR transporter -
EL344_RS17830 3681827..3682288 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
EL344_RS17835 3682293..3684488 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
EL344_RS17840 3684646..3685200 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
EL344_RS17845 3685289..3685867 + 579 WP_003114949.1 HD domain-containing protein Toxin
EL344_RS17850 3685975..3687162 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
EL344_RS17855 3687152..3689323 - 2172 WP_016851733.1 type I secretion system permease/ATPase -
EL344_RS17860 3689313..3690590 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T287586 WP_003114949.1 NZ_LR134309:3685289-3685867 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT287586 WP_003088112.1 NZ_LR134309:3684646-3685200 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References