Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2691359..2692401 Replicon chromosome
Accession NZ_LR134309
Organism Pseudomonas aeruginosa strain NCTC12903

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag EL344_RS13315 Protein ID WP_003153636.1
Coordinates 2691826..2692401 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag EL344_RS13310 Protein ID WP_003050245.1
Coordinates 2691359..2691829 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL344_RS13275 2686751..2688169 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
EL344_RS13280 2688159..2689070 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
EL344_RS13285 2689067..2689759 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
EL344_RS13290 2689756..2690154 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
EL344_RS13295 2690166..2690525 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
EL344_RS13300 2690542..2690775 - 234 WP_003090170.1 TIGR03758 family integrating conjugative element protein -
EL344_RS13305 2690772..2691155 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
EL344_RS13310 2691359..2691829 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
EL344_RS13315 2691826..2692401 + 576 WP_003153636.1 PIN domain-containing protein Toxin
EL344_RS13320 2692419..2693333 + 915 WP_016852809.1 AAA family ATPase -
EL344_RS13325 2693330..2693800 + 471 WP_003090160.1 hypothetical protein -
EL344_RS13330 2693797..2694297 + 501 WP_003090159.1 hypothetical protein -
EL344_RS13335 2694297..2695199 + 903 WP_003090158.1 nucleotidyltransferase domain-containing protein -
EL344_RS13340 2695238..2695963 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2616795..2738499 121704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T287585 WP_003153636.1 NZ_LR134309:2691826-2692401 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT287585 WP_003050245.1 NZ_LR134309:2691359-2691829 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References