Detailed information of TA system TA287580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 4886580..4887217
• Replicon: chromosome
• Accession: NZ_LR134308
• Organism: Pseudomonas aeruginosa strain NCTC11445

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EL295_RS23915
• Protein ID: WP_019725766.1
• Coordinates: 4887035..4887217 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EL295_RS23910
• Protein ID: WP_019725767.1
• Coordinates: 4886580..4887002 (-)
• Length: 141 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL295_RS23885	4882754..4883230	+	477	WP_019725773.1	hypothetical protein	-
EL295_RS23890	4883227..4884150	+	924	WP_019725772.1	hypothetical protein	-
EL295_RS23895	4884147..4884689	+	543	WP_025982284.1	hypothetical protein	-
EL295_RS23900	4884686..4885378	+	693	WP_019725770.1	hypothetical protein	-
EL295_RS23905	4885363..4886334	+	972	WP_025982283.1	hypothetical protein	-
EL295_RS23910	4886580..4887002	-	423	WP_019725767.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EL295_RS23915	4887035..4887217	-	183	WP_019725766.1	type II toxin-antitoxin system HicA family toxin	Toxin
EL295_RS23920	4887793..4888854	+	1062	WP_033974057.1	site-specific integrase	-
EL295_RS23925	4889069..4889293	+	225	WP_060538268.1	hypothetical protein	-
EL295_RS23930	4889642..4890595	+	954	WP_126453352.1	hypothetical protein	-
EL295_RS23935	4891212..4892117	+	906	WP_124187037.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4836000..4900991	64991

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-62)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6970.07 Da
• Isoelectric Point: 10.2954

>T287580 WP_019725766.1 NZ_LR134308:c4887217-4887035 [Pseudomonas aeruginosa]
MKYSEFRRWLKARGVIFEPAKGSHFKVYYGDNQTIFPDHGAKEIGDGLRKKIIKDLGLKD

Nucleotide

• Length: 183 bp

>T287580 NZ_LR134308:c4887217-4887035 [Pseudomonas aeruginosa]
ATGAAGTACAGCGAGTTTCGGCGCTGGTTGAAGGCTCGGGGAGTCATTTTCGAGCCTGCCAAGGGAAGCCACTTCAAGGT
TTACTACGGCGACAACCAGACGATTTTCCCCGACCATGGAGCCAAGGAAATAGGCGATGGGTTGAGGAAGAAGATAATCA
AAGACCTGGGCCTCAAGGATTGA

Antitoxin

Protein

• Length: 141 a.a.
• Molecular weight: 14970.22 Da
• Isoelectric Point: 4.9047

>AT287580 WP_019725767.1 NZ_LR134308:c4887002-4886580 [Pseudomonas aeruginosa]
MFDYPVTVHEEAGSVWVSCDDVPEMASAGDTVDEALLDAVEGLESALSLYVDRRQSIPLPSKGKAGQSIVRLPALTSAKI
ALWNTMLAQNVGKAELARRLGVNRVQVDRLVDLLHGSKIEAVEHALAILGQRLAVTVIAA

Nucleotide

• Length: 423 bp

>AT287580 NZ_LR134308:c4887002-4886580 [Pseudomonas aeruginosa]
ATGTTTGACTATCCCGTAACGGTTCACGAGGAAGCCGGCAGCGTGTGGGTCAGCTGCGACGATGTACCTGAAATGGCGAG
CGCCGGAGATACCGTTGATGAAGCGCTGCTGGACGCTGTGGAAGGCCTAGAGTCGGCCCTGTCGCTCTATGTGGACCGGC
GGCAGTCGATCCCGCTGCCGTCGAAAGGCAAAGCGGGTCAGTCGATCGTTCGATTGCCCGCGCTCACTTCGGCCAAGATT
GCGCTGTGGAACACCATGCTGGCTCAGAACGTAGGGAAGGCGGAACTGGCTCGCCGGCTGGGAGTGAATCGCGTTCAGGT
AGACCGCCTGGTGGATCTGCTCCACGGGTCGAAGATCGAAGCGGTGGAACATGCTCTGGCGATCTTGGGCCAACGGTTGG
CTGTGACTGTCATTGCGGCATAA