287579

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 3611400..3612908 Replicon chromosome
Accession NZ_LR134308
Organism Pseudomonas aeruginosa strain NCTC11445

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag EL295_RS17695 Protein ID WP_003119682.1
Coordinates 3612321..3612908 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag EL295_RS17690 Protein ID WP_033973484.1
Coordinates 3611400..3612254 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL295_RS17675 3606819..3607028 + 210 WP_003115568.1 cold-shock protein -
EL295_RS17680 3607089..3608963 - 1875 WP_003117607.1 MFS transporter -
EL295_RS17685 3609138..3611303 - 2166 WP_003091606.1 TonB-dependent receptor family protein -
EL295_RS17690 3611400..3612254 - 855 WP_033973484.1 AraC family transcriptional regulator Antitoxin
EL295_RS17695 3612321..3612908 - 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
EL295_RS17700 3613174..3616653 + 3480 WP_019371586.1 hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T287579 WP_003119682.1 NZ_LR134308:c3612908-3612321 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31921.23 Da        Isoelectric Point: 7.5295

>AT287579 WP_033973484.1 NZ_LR134308:c3612254-3611400 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVPPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References