Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2732886..2734107 Replicon chromosome
Accession NZ_LR134308
Organism Pseudomonas aeruginosa strain NCTC11445

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag EL295_RS13320 Protein ID WP_003102740.1
Coordinates 2733529..2734107 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL295_RS13315 Protein ID WP_003088112.1
Coordinates 2732886..2733440 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL295_RS13290 2728454..2729005 + 552 WP_003450159.1 XRE family transcriptional regulator -
EL295_RS13295 2729002..2729400 - 399 WP_033974408.1 NADH-quinone oxidoreductase subunit A -
EL295_RS13300 2729413..2729736 - 324 WP_003162861.1 multidrug efflux SMR transporter -
EL295_RS13305 2730067..2730528 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
EL295_RS13310 2730533..2732728 + 2196 WP_010794059.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
EL295_RS13315 2732886..2733440 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
EL295_RS13320 2733529..2734107 + 579 WP_003102740.1 HD domain-containing protein Toxin
EL295_RS13325 2734216..2735403 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
EL295_RS13330 2735393..2737564 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
EL295_RS13335 2737554..2738831 - 1278 WP_003160086.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T287578 WP_003102740.1 NZ_LR134308:2733529-2734107 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT287578 WP_003088112.1 NZ_LR134308:2732886-2733440 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References