287577

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 868573..869831 Replicon chromosome
Accession NZ_LR134308
Organism Pseudomonas aeruginosa strain NCTC11445

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag EL295_RS04445 Protein ID WP_033973427.1
Coordinates 869076..869831 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag EL295_RS04440 Protein ID WP_003086329.1
Coordinates 868573..868941 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL295_RS32925 864736..865011 + 276 WP_169057979.1 zinc ribbon domain-containing protein -
EL295_RS04425 865014..865490 - 477 WP_003086322.1 hypothetical protein -
EL295_RS04430 865569..867158 + 1590 WP_019725935.1 aldehyde dehydrogenase family protein -
EL295_RS04435 867214..868500 + 1287 WP_003163134.1 FAD-binding oxidoreductase -
EL295_RS04440 868573..868941 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
EL295_RS04445 869076..869831 + 756 WP_033973427.1 RES family NAD+ phosphorylase Toxin
EL295_RS04450 870601..871962 + 1362 WP_073657578.1 DNA recombination protein RmuC -
EL295_RS04455 872117..874660 - 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28282.43 Da        Isoelectric Point: 7.7294

>T287577 WP_033973427.1 NZ_LR134308:869076-869831 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAMPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT287577 WP_003086329.1 NZ_LR134308:868573-868941 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References