Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1167256..1168508 Replicon chromosome
Accession NZ_LR134307
Organism Streptococcus milleri strain NCTC10708

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag EL115_RS05835 Protein ID WP_126441501.1
Coordinates 1167256..1168032 (-) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag EL115_RS05840 Protein ID WP_003024006.1
Coordinates 1168032..1168508 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL115_RS05825 1163359..1165173 - 1815 WP_126441499.1 ATP-dependent helicase -
EL115_RS05830 1165160..1167259 - 2100 WP_126441500.1 AAA family ATPase -
EL115_RS05835 1167256..1168032 - 777 WP_126441501.1 zeta toxin family protein Toxin
EL115_RS05840 1168032..1168508 - 477 WP_003024006.1 helix-turn-helix domain-containing protein Antitoxin
EL115_RS05845 1168578..1168865 - 288 WP_126441502.1 hypothetical protein -
EL115_RS05850 1168909..1169298 - 390 WP_126441503.1 chemotaxis protein -
EL115_RS05855 1169295..1169522 - 228 WP_007520115.1 hypothetical protein -
EL115_RS05860 1169577..1170665 - 1089 WP_126441504.1 toprim domain-containing protein -
EL115_RS05865 1170704..1171342 - 639 WP_126441505.1 peptidylprolyl isomerase -
EL115_RS05870 1171477..1172427 + 951 WP_039677842.1 ATP-grasp domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1157830..1207836 50006


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 29576.56 Da        Isoelectric Point: 7.1185

>T287573 WP_126441501.1 NZ_LR134307:c1168032-1167256 [Streptococcus milleri]
MRLEEFSEDEFQKALQRTIRALTRGKTIPEQPQAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEYLVDELSKQGYHLLIEGTLRTTQVPRQTAQLLRKKGYHISLAVIGTKPELSYLSTLIRYEE
LYTINPNQARATPKEHHDGIVEHLVDNLRELENDKLFDRIQIYQRDRTCIYDSETDEISAATVLQGCLFGKWSKVEEEMM
KAGQERLRELVSGNGEKK

Download         Length: 777 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18260.64 Da        Isoelectric Point: 4.3971

>AT287573 WP_003024006.1 NZ_LR134307:c1168508-1168032 [Streptococcus milleri]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEDKMLTPLEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDETNPWILMSDDLAELIHTKIYLVDTFDEIERYNGYLDGIERMLDTVYHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References