Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2271153..2272119 Replicon chromosome
Accession NZ_LR134306
Organism Yersinia pseudotuberculosis strain NCTC3571

Toxin (Protein)


Gene name - Uniprot ID Q66A68
Locus tag EL172_RS10590 Protein ID WP_011192520.1
Coordinates 2271153..2271611 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag EL172_RS10595 Protein ID WP_002210982.1
Coordinates 2271673..2272119 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL172_RS10560 2266967..2267632 + 666 WP_011192521.1 phage shock protein PspA -
EL172_RS10565 2267794..2268021 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
EL172_RS10570 2268021..2268380 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
EL172_RS10575 2268465..2268707 + 243 WP_080987533.1 phage shock protein PspD -
EL172_RS10580 2268688..2270085 + 1398 WP_057532366.1 YcjX family protein -
EL172_RS10585 2270082..2271143 + 1062 WP_050320586.1 YcjF family protein -
EL172_RS10590 2271153..2271611 - 459 WP_011192520.1 RES family NAD+ phosphorylase Toxin
EL172_RS10595 2271673..2272119 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
EL172_RS10600 2272457..2274034 + 1578 WP_050320587.1 transcriptional regulator TyrR -
EL172_RS10605 2274181..2274684 - 504 WP_002210984.1 thiol peroxidase -
EL172_RS10610 2274847..2275821 + 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -
EL172_RS10615 2275880..2276587 - 708 WP_002220315.1 murein tripeptide amidase MpaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17008.41 Da        Isoelectric Point: 4.8732

>T287565 WP_011192520.1 NZ_LR134306:c2271611-2271153 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT287565 WP_002210982.1 NZ_LR134306:c2272119-2271673 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q66A68

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References