Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1202443..1203115 Replicon chromosome
Accession NZ_LR134306
Organism Yersinia pseudotuberculosis strain NCTC3571

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag EL172_RS05340 Protein ID WP_002215144.1
Coordinates 1202690..1203115 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag EL172_RS05335 Protein ID WP_002209939.1
Coordinates 1202443..1202709 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL172_RS05315 1198217..1199320 + 1104 WP_050320984.1 hypothetical protein -
EL172_RS05320 1199521..1200222 + 702 WP_002209942.1 hemolysin III family protein -
EL172_RS05325 1200565..1201062 + 498 WP_002209941.1 DUF2165 family protein -
EL172_RS05330 1201135..1202127 - 993 WP_002209940.1 tRNA-modifying protein YgfZ -
EL172_RS05335 1202443..1202709 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
EL172_RS05340 1202690..1203115 + 426 WP_002215144.1 protein YgfX Toxin
EL172_RS05345 1203115..1203813 + 699 WP_002209937.1 two-component system response regulator CreB -
EL172_RS05350 1203838..1205271 + 1434 WP_012104678.1 two-component system sensor histidine kinase CreC -
EL172_RS05355 1205356..1206813 + 1458 WP_012303664.1 cell envelope integrity protein CreD -
EL172_RS05360 1206898..1207416 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T287563 WP_002215144.1 NZ_LR134306:1202690-1203115 [Yersinia pseudotuberculosis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT287563 WP_002209939.1 NZ_LR134306:1202443-1202709 [Yersinia pseudotuberculosis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References