Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1839596..1840110 Replicon chromosome
Accession NZ_LR134305
Organism Staphylococcus aureus strain NCTC1803

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag EL119_RS09700 Protein ID WP_000581796.1
Coordinates 1839596..1839805 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag EL119_RS09705 Protein ID WP_000138932.1
Coordinates 1839817..1840110 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL119_RS09680 1835101..1836459 - 1359 WP_000611455.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
EL119_RS09685 1836474..1837544 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
EL119_RS09690 1837862..1839064 + 1203 WP_001109939.1 rod shape-determining protein RodA -
EL119_RS09695 1839331..1839468 - 138 WP_000828354.1 hypothetical protein -
EL119_RS09700 1839596..1839805 - 210 WP_000581796.1 heavy-metal-associated domain-containing protein Toxin
EL119_RS09705 1839817..1840110 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
EL119_RS09710 1840276..1841760 + 1485 WP_000571549.1 cardiolipin synthase -
EL119_RS09715 1841788..1842435 + 648 WP_065315756.1 HD domain-containing protein -
EL119_RS09730 1843172..1844044 - 873 WP_000725802.1 membrane protein insertase YidC -
EL119_RS09735 1844130..1844771 - 642 WP_000483160.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7859.77 Da        Isoelectric Point: 4.1008

>T287557 WP_000581796.1 NZ_LR134305:c1839805-1839596 [Staphylococcus aureus]
MIHQNTIYTSGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT287557 WP_000138932.1 NZ_LR134305:c1840110-1839817 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References