Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1598104..1598880 Replicon chromosome
Accession NZ_LR134305
Organism Staphylococcus aureus strain NCTC1803

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag EL119_RS08205 Protein ID WP_000031108.1
Coordinates 1598104..1598256 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag EL119_RS08210 Protein ID WP_001251219.1
Coordinates 1598281..1598880 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL119_RS08180 1594113..1594934 + 822 WP_000669385.1 RluA family pseudouridine synthase -
EL119_RS08185 1595385..1596770 - 1386 WP_000116236.1 class II fumarate hydratase -
EL119_RS08190 1596966..1597361 - 396 WP_000901023.1 hypothetical protein -
EL119_RS08205 1598104..1598256 - 153 WP_000031108.1 hypothetical protein Toxin
EL119_RS08210 1598281..1598880 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
EL119_RS08215 1599039..1599509 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EL119_RS08220 1599514..1600641 - 1128 WP_000379979.1 tRNA epoxyqueuosine(34) reductase QueG -
EL119_RS08225 1600792..1601514 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
EL119_RS08230 1601507..1602964 - 1458 WP_000649892.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T287555 WP_000031108.1 NZ_LR134305:c1598256-1598104 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT287555 WP_001251219.1 NZ_LR134305:c1598880-1598281 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References