Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2110516..2111030 Replicon chromosome
Accession NZ_LR134304
Organism Staphylococcus schweitzeri strain NCTC13712

Toxin (Protein)


Gene name TsdT Uniprot ID A0A2K4AEQ4
Locus tag EL116_RS10420 Protein ID WP_047531400.1
Coordinates 2110516..2110725 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A2K4AFL9
Locus tag EL116_RS10425 Protein ID WP_047427877.1
Coordinates 2110737..2111030 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL116_RS10400 2105852..2107210 - 1359 WP_047550961.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
EL116_RS10405 2107225..2108295 - 1071 WP_047450612.1 D-alanine--D-alanine ligase -
EL116_RS10410 2108614..2109816 + 1203 WP_047427869.1 rod shape-determining protein RodA -
EL116_RS10415 2110248..2110385 - 138 WP_000828355.1 hypothetical protein -
EL116_RS10420 2110516..2110725 - 210 WP_047531400.1 heavy-metal-associated domain-containing protein Toxin
EL116_RS10425 2110737..2111030 - 294 WP_047427877.1 copper-sensing transcriptional repressor CsoR Antitoxin
EL116_RS10430 2111198..2112682 + 1485 WP_047550965.1 cardiolipin synthase -
EL116_RS10435 2112710..2113357 + 648 WP_047550968.1 HD domain-containing protein -
EL116_RS10440 2113819..2114688 - 870 WP_047427885.1 membrane protein insertase YidC -
EL116_RS10445 2114774..2115415 - 642 WP_047531398.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7875.87 Da        Isoelectric Point: 4.1015

>T287546 WP_047531400.1 NZ_LR134304:c2110725-2110516 [Staphylococcus schweitzeri]
MVYQNTVYVAGIETEEQVKQLTERISNMIGVHNVNVNMFDGEVVVAYETPANLNSIEKEIYDTGYKIVY

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11199.84 Da        Isoelectric Point: 6.7122

>AT287546 WP_047427877.1 NZ_LR134304:c2111030-2110737 [Staphylococcus schweitzeri]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVKQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4AEQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K4AFL9

References