287545

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2090202..2090731 Replicon chromosome
Accession NZ_LR134304
Organism Staphylococcus schweitzeri strain NCTC13712

Toxin (Protein)


Gene name mazF Uniprot ID A0A2K4AER0
Locus tag EL116_RS10325 Protein ID WP_047427839.1
Coordinates 2090202..2090564 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag EL116_RS10330 Protein ID WP_000948331.1
Coordinates 2090561..2090731 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL116_RS10300 2087184..2087954 - 771 WP_047427832.1 RNA polymerase sigma factor SigB -
EL116_RS10305 2087929..2088408 - 480 WP_001190826.1 anti-sigma B factor RsbW -
EL116_RS10310 2088410..2088736 - 327 WP_047427835.1 anti-sigma factor antagonist -
EL116_RS10315 2088853..2089854 - 1002 WP_000390825.1 PP2C family protein-serine/threonine phosphatase -
EL116_RS10325 2090202..2090564 - 363 WP_047427839.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL116_RS10330 2090561..2090731 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EL116_RS10335 2090816..2091964 - 1149 WP_047550937.1 alanine racemase -
EL116_RS10340 2092033..2092392 - 360 WP_047427846.1 holo-ACP synthase -
EL116_RS10345 2092396..2092899 - 504 WP_047427849.1 PH domain-containing protein -
EL116_RS10350 2092886..2094478 - 1593 WP_047550940.1 PH domain-containing protein -
EL116_RS10355 2094471..2094950 - 480 WP_047550944.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13474.78 Da        Isoelectric Point: 10.2631

>T287545 WP_047427839.1 NZ_LR134304:c2090564-2090202 [Staphylococcus schweitzeri]
MIKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDNKMKEVDNALMISLGLNTMAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT287545 WP_000948331.1 NZ_LR134304:c2090731-2090561 [Staphylococcus schweitzeri]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4AER0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References