287544

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1935844..1936620 Replicon chromosome
Accession NZ_LR134304
Organism Staphylococcus schweitzeri strain NCTC13712

Toxin (Protein)


Gene name tsbT Uniprot ID A0A2K4AF95
Locus tag EL116_RS09460 Protein ID WP_047428523.1
Coordinates 1935844..1935996 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A2K4AFI4
Locus tag EL116_RS09465 Protein ID WP_047448485.1
Coordinates 1936021..1936620 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL116_RS09440 1931485..1932306 + 822 WP_047531479.1 RluA family pseudouridine synthase -
EL116_RS09450 1933362..1934747 - 1386 WP_000116236.1 class II fumarate hydratase -
EL116_RS09455 1934944..1935339 - 396 WP_047428520.1 hypothetical protein -
EL116_RS09460 1935844..1935996 - 153 WP_047428523.1 hypothetical protein Toxin
EL116_RS09465 1936021..1936620 - 600 WP_047448485.1 glucosamine-6-phosphate isomerase Antitoxin
EL116_RS09470 1936779..1937249 - 471 WP_047428531.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EL116_RS09475 1937251..1938381 - 1131 WP_047531481.1 tRNA epoxyqueuosine(34) reductase QueG -
EL116_RS09480 1938531..1939253 - 723 WP_047531483.1 amino acid ABC transporter ATP-binding protein -
EL116_RS09485 1939246..1940703 - 1458 WP_047531485.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5949.32 Da        Isoelectric Point: 3.9607

>T287544 WP_047428523.1 NZ_LR134304:c1935996-1935844 [Staphylococcus schweitzeri]
MSKEKNPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22361.44 Da        Isoelectric Point: 4.9684

>AT287544 WP_047448485.1 NZ_LR134304:c1936620-1936021 [Staphylococcus schweitzeri]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPITYEKDAIELISDKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKQDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4AF95

Antitoxin

Source ID Structure
AlphaFold DB A0A2K4AFI4

References