Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 3817311..3818127 Replicon chromosome
Accession NZ_LR134303
Organism Shewanella putrefaciens strain NCTC12093

Toxin (Protein)


Gene name hepT Uniprot ID A0A252EQR5
Locus tag EL161_RS16950 Protein ID WP_069455295.1
Coordinates 3817311..3817712 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID A0A501X4H4
Locus tag EL161_RS16955 Protein ID WP_069455294.1
Coordinates 3817705..3818127 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL161_RS16920 3813083..3813430 + 348 WP_037428262.1 hypothetical protein -
EL161_RS16925 3813427..3814107 - 681 WP_126512863.1 NAD-dependent deacylase -
EL161_RS16930 3814211..3814810 - 600 WP_126512864.1 metallophosphoesterase -
EL161_RS16935 3814819..3815232 - 414 WP_069455298.1 hypothetical protein -
EL161_RS16940 3815229..3815531 - 303 WP_126512865.1 hypothetical protein -
EL161_RS16945 3816086..3817117 + 1032 WP_126512866.1 dTDP-glucose 4,6-dehydratase -
EL161_RS16950 3817311..3817712 - 402 WP_069455295.1 type II toxin-antitoxin system toxin Toxin
EL161_RS16955 3817705..3818127 - 423 WP_069455294.1 type II toxin-antitoxin system antitoxin Antitoxin
EL161_RS16960 3818234..3819001 - 768 WP_126512867.1 HutD family protein -
EL161_RS16965 3819277..3819729 - 453 WP_164718002.1 copper resistance protein NlpE -
EL161_RS16970 3820094..3821455 + 1362 WP_126512869.1 GAF domain-containing sensor histidine kinase -
EL161_RS16975 3821578..3822468 + 891 WP_126513293.1 glucose-1-phosphate thymidylyltransferase RfbA -
EL161_RS16980 3822455..3822991 + 537 WP_011716460.1 dTDP-4-dehydrorhamnose 3,5-epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(12-129)

Antitoxin

Polymerase beta, nucleotidyltransferase

(7-97)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15296.57 Da        Isoelectric Point: 6.3185

>T287534 WP_069455295.1 NZ_LR134303:c3817712-3817311 [Shewanella putrefaciens]
MNDIIINKIATIKRCIKRIQQVYGDGSQFKQDFTLQDSVILNLQRCCEACIDIANHINRQQQLGIPQSSRDSFTLLAQNN
LITQPLADNLKKMVGLRNIAVHDYQELNLDIVVHVVQHHLEDFEQFIDVIKAE

Download         Length: 402 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15795.88 Da        Isoelectric Point: 5.1520

>AT287534 WP_069455294.1 NZ_LR134303:c3818127-3817705 [Shewanella putrefaciens]
MQQLNEKKIIKLLRDNIPKLQLIYLFGSYSQGTQHRNSDIDIAVLAADTLDNIARWELAQKLASALDSDVDLVDLRSAST
VLCQQVVTQGKQLWGTQQDDELFAVKTISMYQHLQAERQAIIDDVMANTAAKDHRGSHFE

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A252EQR5

Antitoxin

Source ID Structure
AlphaFold DB A0A501X4H4

References