Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3924145..3924769 Replicon chromosome
Accession NZ_LR134302
Organism Achromobacter spanius strain NCTC13519

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL258_RS17810 Protein ID WP_100857904.1
Coordinates 3924587..3924769 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL258_RS17805 Protein ID WP_100857414.1
Coordinates 3924145..3924537 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL258_RS17785 3919644..3921086 - 1443 WP_100857418.1 sensor histidine kinase -
EL258_RS17790 3921090..3921794 - 705 WP_100857417.1 response regulator transcription factor -
EL258_RS17795 3921985..3923325 + 1341 WP_100857416.1 CitMHS family transporter -
EL258_RS17800 3923363..3924103 + 741 WP_100857415.1 SDR family oxidoreductase -
EL258_RS17805 3924145..3924537 - 393 WP_100857414.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL258_RS17810 3924587..3924769 - 183 WP_100857904.1 type II toxin-antitoxin system HicA family toxin Toxin
EL258_RS17815 3924938..3925279 + 342 WP_100857413.1 hypothetical protein -
EL258_RS17820 3925299..3925736 - 438 WP_100857412.1 hypothetical protein -
EL258_RS17825 3926204..3926407 + 204 WP_050448526.1 cold-shock protein -
EL258_RS17830 3926462..3926719 + 258 WP_100857411.1 hypothetical protein -
EL258_RS17835 3926912..3927829 + 918 WP_100857410.1 DUF808 domain-containing protein -
EL258_RS17840 3928103..3928972 + 870 WP_100857409.1 hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6739.95 Da        Isoelectric Point: 12.1585

>T287526 WP_100857904.1 NZ_LR134302:c3924769-3924587 [Achromobacter spanius]
MNSREIIRQLRQAGWVFRHAKGSHHIFVHPQKAGHISVPHPKKDLGIGLVTKLLTQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13901.74 Da        Isoelectric Point: 4.2687

>AT287526 WP_100857414.1 NZ_LR134302:c3924537-3924145 [Achromobacter spanius]
MKYPIAIEPGSETQAWGVVVPDLPGCFSAADSGIDEAIENAKEAIELWIETALDSGTPVPVATSIAGHQANPEFAGWVWA
IVEIDPAVMDDTIERINITLPRRILARIDAKARAAGESRSGYIAHLALTH

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References