287525

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3738287..3739329 Replicon chromosome
Accession NZ_LR134302
Organism Achromobacter spanius strain NCTC13519

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag EL258_RS16920 Protein ID WP_003109777.1
Coordinates 3738287..3738862 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag EL258_RS16925 Protein ID WP_003050245.1
Coordinates 3738859..3739329 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL258_RS16895 3734725..3735450 - 726 WP_003050273.1 CBASS effector endonuclease NucC -
EL258_RS16900 3735489..3736391 - 903 WP_003105624.1 nucleotidyltransferase domain-containing protein -
EL258_RS16905 3736391..3736891 - 501 WP_003090159.1 hypothetical protein -
EL258_RS16910 3736888..3737358 - 471 WP_003105626.1 hypothetical protein -
EL258_RS16915 3737355..3738269 - 915 WP_003105629.1 AAA family ATPase -
EL258_RS16920 3738287..3738862 - 576 WP_003109777.1 PIN domain-containing protein Toxin
EL258_RS16925 3738859..3739329 - 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
EL258_RS16930 3739533..3739916 + 384 WP_003120001.1 RAQPRD family integrative conjugative element protein -
EL258_RS16935 3739913..3740146 + 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
EL258_RS16940 3740163..3740522 + 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
EL258_RS16945 3740534..3740932 + 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
EL258_RS16950 3740929..3741621 + 693 WP_003105641.1 TIGR03746 family integrating conjugative element protein -
EL258_RS16955 3741618..3742529 + 912 WP_003105643.1 TIGR03749 family integrating conjugative element protein -
EL258_RS16960 3742519..3743937 + 1419 WP_020924934.1 TIGR03752 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21644.79 Da        Isoelectric Point: 5.6172

>T287525 WP_003109777.1 NZ_LR134302:c3738862-3738287 [Achromobacter spanius]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT287525 WP_003050245.1 NZ_LR134302:c3739329-3738859 [Achromobacter spanius]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References