Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 417765..418431 Replicon chromosome
Accession NZ_LR134302
Organism Achromobacter spanius strain NCTC13519

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL258_RS01840 Protein ID WP_100857686.1
Coordinates 417765..418211 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL258_RS01845 Protein ID WP_100855259.1
Coordinates 418195..418431 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL258_RS01825 413996..414991 - 996 WP_100855260.1 tripartite tricarboxylate transporter substrate binding protein -
EL258_RS01830 415214..416989 + 1776 WP_167401007.1 dihydroxy-acid dehydratase -
EL258_RS01835 417011..417694 + 684 WP_167401006.1 GntR family transcriptional regulator -
EL258_RS01840 417765..418211 - 447 WP_100857686.1 PIN domain-containing protein Toxin
EL258_RS01845 418195..418431 - 237 WP_100855259.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL258_RS01850 418531..419439 - 909 WP_100855258.1 LysR family transcriptional regulator -
EL258_RS01855 419563..420525 + 963 WP_100855257.1 NAD-binding protein -
EL258_RS01860 420522..421376 + 855 WP_100855256.1 3-keto-5-aminohexanoate cleavage protein -
EL258_RS01865 421618..421776 + 159 WP_100855255.1 periplasmic nitrate reductase, NapE protein -
EL258_RS01870 421800..422117 + 318 WP_100855254.1 chaperone NapD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-119)

Antitoxin

SpoVT-AbrB domain

(5-44)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 16903.63 Da        Isoelectric Point: 5.2332

>T287521 WP_100857686.1 NZ_LR134302:c418211-417765 [Achromobacter spanius]
IAVISDARVFLDSNILIYLLSADARRADIAEVLLKGKPFISVQVLNEVTNVCVRKLKRQWEETNEFLAMVRMFCRVVPLT
VDVHDKARQLAERYQMSFYDACIAASALAVDCQILYTEDMQADMSIDQRLTLINPFTQQRSRLAEPGF

Download         Length: 447 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8875.07 Da        Isoelectric Point: 7.2053

>AT287521 WP_100855259.1 NZ_LR134302:c418431-418195 [Achromobacter spanius]
MRVAKWGNSLAVRLPASVVDALNLQEGDDIEIHIQGDRHFEVRKTAGEEGVLAKLRQFRGMLPADFVFNRDEANRRDK

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References