Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5799185..5799690 Replicon chromosome
Accession NZ_LR134300
Organism Pseudomonas fluorescens strain NCTC10783

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag EL286_RS27555 Protein ID WP_003121619.1
Coordinates 5799185..5799466 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag EL286_RS27560 Protein ID WP_003112628.1
Coordinates 5799463..5799690 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL286_RS27530 5794436..5795785 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
EL286_RS27535 5795834..5796520 + 687 WP_003083762.1 FadR family transcriptional regulator -
EL286_RS27540 5796621..5797355 + 735 WP_003117208.1 GntR family transcriptional regulator -
EL286_RS27545 5797559..5797945 + 387 WP_014602345.1 aegerolysin family protein -
EL286_RS27550 5797977..5798885 - 909 WP_016561475.1 LysR family transcriptional regulator -
EL286_RS27555 5799185..5799466 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
EL286_RS27560 5799463..5799690 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
EL286_RS27565 5799866..5800486 - 621 WP_003101226.1 hypothetical protein -
EL286_RS27570 5800587..5801087 + 501 WP_003112629.1 LEA type 2 family protein -
EL286_RS27575 5801160..5801501 + 342 WP_003101229.1 alkylphosphonate utilization protein -
EL286_RS27580 5801583..5803010 - 1428 WP_003083784.1 GABA permease -
EL286_RS27585 5803179..5804670 - 1492 Protein_5317 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T287518 WP_003121619.1 NZ_LR134300:c5799466-5799185 [Pseudomonas fluorescens]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT287518 WP_003112628.1 NZ_LR134300:c5799690-5799463 [Pseudomonas fluorescens]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References