Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3491206..3491846 Replicon chromosome
Accession NZ_LR134300
Organism Pseudomonas fluorescens strain NCTC10783

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL286_RS16790 Protein ID WP_003105740.1
Coordinates 3491206..3491616 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q6X2S2
Locus tag EL286_RS16795 Protein ID WP_003158175.1
Coordinates 3491616..3491846 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL286_RS16745 3487048..3487245 + 198 WP_003105756.1 hypothetical protein -
EL286_RS16750 3487401..3488129 + 729 WP_003105754.1 TIGR03761 family integrating conjugative element protein -
EL286_RS16755 3488135..3488683 + 549 WP_003105753.1 DUF3158 family protein -
EL286_RS16760 3488730..3489569 + 840 WP_126450664.1 Rha family transcriptional regulator -
EL286_RS16765 3489599..3490087 + 489 WP_003105748.1 single-stranded DNA-binding protein -
EL286_RS16770 3490195..3490440 + 246 WP_023102333.1 CrpP family protein -
EL286_RS16775 3490506..3490724 - 219 WP_003105747.1 hypothetical protein -
EL286_RS16785 3490924..3491184 - 261 WP_003105742.1 hypothetical protein -
EL286_RS16790 3491206..3491616 - 411 WP_003105740.1 tRNA(fMet)-specific endonuclease VapC Toxin
EL286_RS16795 3491616..3491846 - 231 WP_003158175.1 antitoxin Antitoxin
EL286_RS16800 3492102..3494021 + 1920 WP_004352838.1 type I DNA topoisomerase -
EL286_RS16805 3494329..3494538 + 210 WP_003105733.1 cold-shock protein -
EL286_RS16810 3494759..3496648 + 1890 WP_003105732.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3471634..3610133 138499


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-35)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15450.81 Da        Isoelectric Point: 7.3233

>T287515 WP_003105740.1 NZ_LR134300:c3491616-3491206 [Pseudomonas fluorescens]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVVPIV

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8480.41 Da        Isoelectric Point: 4.2821

>AT287515 WP_003158175.1 NZ_LR134300:c3491846-3491616 [Pseudomonas fluorescens]
MEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVVVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q6X2S2

References