Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 3423632..3424890 Replicon chromosome
Accession NZ_LR134300
Organism Pseudomonas fluorescens strain NCTC10783

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag EL286_RS16395 Protein ID WP_003112528.1
Coordinates 3423632..3424387 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag EL286_RS16400 Protein ID WP_003086329.1
Coordinates 3424522..3424890 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL286_RS16385 3418805..3421348 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
EL286_RS16390 3421503..3422864 - 1362 WP_073647918.1 DNA recombination protein RmuC -
EL286_RS16395 3423632..3424387 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
EL286_RS16400 3424522..3424890 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
EL286_RS16405 3424963..3426249 - 1287 WP_023083139.1 FAD-binding oxidoreductase -
EL286_RS16410 3426305..3427895 - 1591 Protein_3162 aldehyde dehydrogenase family protein -
EL286_RS16415 3427974..3428450 + 477 WP_003112531.1 hypothetical protein -
EL286_RS32815 3428453..3428728 - 276 WP_172616476.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T287514 WP_003112528.1 NZ_LR134300:c3424387-3423632 [Pseudomonas fluorescens]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT287514 WP_003086329.1 NZ_LR134300:c3424890-3424522 [Pseudomonas fluorescens]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References