Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 3759122..3759675 Replicon chromosome
Accession NZ_LR134299
Organism Pseudomonas putida strain NCTC13186

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag EL224_RS17530 Protein ID WP_010953434.1
Coordinates 3759122..3759415 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q88JZ4
Locus tag EL224_RS17535 Protein ID WP_010953433.1
Coordinates 3759403..3759675 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL224_RS17500 3754276..3754794 - 519 WP_049587643.1 DUF1993 domain-containing protein -
EL224_RS28975 3754937..3755149 - 213 WP_061405625.1 hypothetical protein -
EL224_RS17510 3755146..3755355 - 210 WP_010953438.1 4-oxalocrotonate tautomerase family protein -
EL224_RS17515 3755425..3756156 - 732 WP_010953437.1 SDR family oxidoreductase -
EL224_RS17520 3756270..3757196 + 927 WP_010953436.1 LysR family transcriptional regulator -
EL224_RS17525 3757719..3759128 + 1410 WP_010953435.1 site-specific integrase -
EL224_RS17530 3759122..3759415 - 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL224_RS17535 3759403..3759675 - 273 WP_010953433.1 CopG family ribbon-helix-helix protein Antitoxin
EL224_RS17540 3759800..3760045 - 246 WP_010953432.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EL224_RS17545 3760307..3760579 + 273 WP_031299398.1 hypothetical protein -
EL224_RS17550 3760677..3761645 + 969 WP_031299399.1 DUF932 domain-containing protein -
EL224_RS17555 3761725..3762729 + 1005 WP_010953429.1 YqaJ viral recombinase family protein -
EL224_RS17560 3762822..3763772 + 951 WP_031299400.1 hypothetical protein -
EL224_RS17565 3763744..3764103 + 360 Protein_3373 DNA repair protein RadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T287507 WP_010953434.1 NZ_LR134299:c3759415-3759122 [Pseudomonas putida]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10373.53 Da        Isoelectric Point: 5.5744

>AT287507 WP_010953433.1 NZ_LR134299:c3759675-3759403 [Pseudomonas putida]
MATSIKIDDDLKGRIQHLACLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB Q88JZ4

References