Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4020629..4021443 Replicon chromosome
Accession NZ_LR134296
Organism Escherichia coli strain NCTC9041

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag EL151_RS19645 Protein ID WP_001054376.1
Coordinates 4020629..4020886 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag EL151_RS19650 Protein ID WP_001309181.1
Coordinates 4020898..4021443 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL151_RS19625 4015917..4017023 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
EL151_RS19630 4017088..4018068 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
EL151_RS19635 4018651..4019891 - 1241 Protein_3795 helicase YjhR -
EL151_RS19640 4020007..4020252 + 246 Protein_3796 GNAT family N-acetyltransferase -
EL151_RS19645 4020629..4020886 + 258 WP_001054376.1 hypothetical protein Toxin
EL151_RS19650 4020898..4021443 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
EL151_RS19655 4021499..4022245 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
EL151_RS19660 4022414..4022632 + 219 Protein_3800 hypothetical protein -
EL151_RS23015 4022670..4022786 + 117 Protein_3801 VOC family protein -
EL151_RS19665 4023031..4024152 + 1122 WP_000010829.1 M42 family metallopeptidase -
EL151_RS19670 4024149..4024427 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
EL151_RS19675 4024439..4025752 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4013122..4029667 16545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T287500 WP_001054376.1 NZ_LR134296:4020629-4020886 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT287500 WP_001309181.1 NZ_LR134296:4020898-4021443 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References