28750

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1691416..1692032 Replicon chromosome
Accession NC_020089
Organism Mycobacterium tuberculosis 7199-99

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag MT7199_RS07925 Protein ID WP_003407593.1
Coordinates 1691715..1692032 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag MT7199_RS07920 Protein ID WP_003900349.1
Coordinates 1691416..1691718 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT7199_RS07910 1687302..1689149 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
MT7199_RS07915 1689150..1691402 + 2253 WP_015345074.1 methylmalonyl-CoA mutase -
MT7199_RS07920 1691416..1691718 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
MT7199_RS07925 1691715..1692032 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
MT7199_RS07930 1692029..1693033 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
MT7199_RS07935 1693086..1694375 + 1290 WP_015345075.1 serine hydrolase -
MT7199_RS07940 1694448..1695221 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
MT7199_RS07945 1695279..1695491 - 213 WP_003898900.1 dodecin family protein -
MT7199_RS22445 1695501..1695725 - 225 WP_160522526.1 NUDIX domain-containing protein -
MT7199_RS07955 1695995..1697023 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T28750 WP_003407593.1 NC_020089:1691715-1692032 [Mycobacterium tuberculosis 7199-99]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T28750 NC_020089:1691715-1692032 [Mycobacterium tuberculosis 7199-99]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT28750 WP_003900349.1 NC_020089:1691416-1691718 [Mycobacterium tuberculosis 7199-99]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT28750 NC_020089:1691416-1691718 [Mycobacterium tuberculosis 7199-99]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB G0TJ73

References