Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3984461..3985037 Replicon chromosome
Accession NZ_LR134296
Organism Escherichia coli strain NCTC9041

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag EL151_RS19460 Protein ID WP_001297643.1
Coordinates 3984750..3985037 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag EL151_RS19455 Protein ID WP_000063156.1
Coordinates 3984461..3984763 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL151_RS19440 3981057..3983207 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
EL151_RS19445 3983257..3983460 + 204 WP_000467859.1 YbdD/YjiX family protein -
EL151_RS19450 3983471..3984427 + 957 WP_001297640.1 GTPase -
EL151_RS19455 3984461..3984763 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
EL151_RS19460 3984750..3985037 - 288 WP_001297643.1 BrnT family toxin Toxin
EL151_RS19465 3985236..3985933 - 698 Protein_3762 IS1 family transposase -
EL151_RS19470 3985990..3986085 + 96 Protein_3763 dienelactone hydrolase family protein -
EL151_RS19475 3986231..3987463 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
EL151_RS19480 3987504..3988784 + 1281 WP_001037380.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T287499 WP_001297643.1 NZ_LR134296:c3985037-3984750 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT287499 WP_000063156.1 NZ_LR134296:c3984763-3984461 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References