Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2247540..2248066 Replicon chromosome
Accession NZ_LR134296
Organism Escherichia coli strain NCTC9041

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL151_RS10870 Protein ID WP_000323025.1
Coordinates 2247779..2248066 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL151_RS10865 Protein ID WP_000534858.1
Coordinates 2247540..2247779 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL151_RS10830 2242654..2242905 + 252 Protein_2087 DUF977 family protein -
EL151_RS10835 2242902..2243258 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EL151_RS22980 2243869..2244156 + 288 Protein_2089 hypothetical protein -
EL151_RS10850 2244925..2246238 + 1314 WP_000589005.1 ISNCY family transposase -
EL151_RS10855 2246675..2247007 - 333 WP_001301033.1 protein FlxA -
EL151_RS10860 2247210..2247515 - 306 WP_001326990.1 hypothetical protein -
EL151_RS10865 2247540..2247779 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL151_RS10870 2247779..2248066 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL151_RS10875 2248138..2248293 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL151_RS10880 2248510..2248761 + 252 WP_000980994.1 hypothetical protein -
EL151_RS10885 2248828..2249106 + 279 WP_012304870.1 hypothetical protein -
EL151_RS10890 2249108..2250157 + 1050 WP_001265198.1 DUF968 domain-containing protein -
EL151_RS10895 2250171..2250923 + 753 WP_001047135.1 antitermination protein -
EL151_RS10900 2251201..2251290 - 90 WP_120795389.1 hypothetical protein -
EL151_RS10905 2251345..2251557 - 213 WP_000087756.1 cold shock-like protein CspF -
EL151_RS10910 2251858..2252073 + 216 WP_000066484.1 cold shock-like protein CspB -
EL151_RS23100 2252437..2252607 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL151_RS10915 2252827..2253042 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2236553..2268929 32376


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287493 WP_000323025.1 NZ_LR134296:2247779-2248066 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287493 WP_000534858.1 NZ_LR134296:2247540-2247779 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References