287493

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2247540..2248066 Replicon chromosome
Accession NZ_LR134296
Organism Escherichia coli strain NCTC9041

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL151_RS10870 Protein ID WP_000323025.1
Coordinates 2247779..2248066 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL151_RS10865 Protein ID WP_000534858.1
Coordinates 2247540..2247779 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL151_RS10830 2242654..2242905 + 252 Protein_2087 DUF977 family protein -
EL151_RS10835 2242902..2243258 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EL151_RS22980 2243869..2244156 + 288 Protein_2089 hypothetical protein -
EL151_RS10850 2244925..2246238 + 1314 WP_000589005.1 ISNCY family transposase -
EL151_RS10855 2246675..2247007 - 333 WP_001301033.1 protein FlxA -
EL151_RS10860 2247210..2247515 - 306 WP_001326990.1 hypothetical protein -
EL151_RS10865 2247540..2247779 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL151_RS10870 2247779..2248066 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL151_RS10875 2248138..2248293 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL151_RS10880 2248510..2248761 + 252 WP_000980994.1 hypothetical protein -
EL151_RS10885 2248828..2249106 + 279 WP_012304870.1 hypothetical protein -
EL151_RS10890 2249108..2250157 + 1050 WP_001265198.1 DUF968 domain-containing protein -
EL151_RS10895 2250171..2250923 + 753 WP_001047135.1 antitermination protein -
EL151_RS10900 2251201..2251290 - 90 WP_120795389.1 hypothetical protein -
EL151_RS10905 2251345..2251557 - 213 WP_000087756.1 cold shock-like protein CspF -
EL151_RS10910 2251858..2252073 + 216 WP_000066484.1 cold shock-like protein CspB -
EL151_RS23100 2252437..2252607 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL151_RS10915 2252827..2253042 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2236553..2268929 32376


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287493 WP_000323025.1 NZ_LR134296:2247779-2248066 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287493 WP_000534858.1 NZ_LR134296:2247540-2247779 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References