Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4233373..4233870 Replicon chromosome
Accession NZ_LR134295
Organism Escherichia coli strain NCTC9080

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag EL145_RS20460 Protein ID WP_001173343.1
Coordinates 4233373..4233546 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag EL145_RS20465 Protein ID WP_000398619.1
Coordinates 4233574..4233870 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL145_RS20450 4230038..4231495 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
EL145_RS20455 4231732..4233249 + 1518 WP_072663458.1 lysine--tRNA ligase -
EL145_RS20460 4233373..4233546 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
EL145_RS20465 4233574..4233870 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
EL145_RS20470 4234097..4234369 - 273 WP_000405651.1 N-acetyltransferase -
EL145_RS20475 4234381..4234611 - 231 WP_032202296.1 (4Fe-4S)-binding protein -
EL145_RS20480 4234792..4236423 + 1632 WP_001216477.1 sensor histidine kinase -
EL145_RS20485 4236420..4237139 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T287483 WP_001173343.1 NZ_LR134295:c4233546-4233373 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT287483 WP_000398619.1 NZ_LR134295:c4233870-4233574 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References