Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2516677..2517203 Replicon chromosome
Accession NZ_LR134295
Organism Escherichia coli strain NCTC9080

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL145_RS12025 Protein ID WP_000323025.1
Coordinates 2516677..2516964 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL145_RS12030 Protein ID WP_000534858.1
Coordinates 2516964..2517203 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL145_RS11985 2512067..2512282 - 216 WP_000839565.1 phage lysis protein EssD -
EL145_RS11990 2512534..2512908 - 375 WP_001348108.1 hypothetical protein -
EL145_RS11995 2513080..2513508 - 429 WP_000506936.1 cell envelope integrity protein TolA -
EL145_RS12000 2514553..2515095 - 543 WP_000640161.1 DUF1133 family protein -
EL145_RS12005 2515092..2515382 - 291 WP_000247763.1 DUF1364 domain-containing protein -
EL145_RS12010 2515382..2515981 - 600 WP_025670565.1 DUF1367 family protein -
EL145_RS12020 2516450..2516605 - 156 WP_000813269.1 type I toxin-antitoxin system toxin HokD -
EL145_RS12025 2516677..2516964 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL145_RS12030 2516964..2517203 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL145_RS12035 2517228..2517533 + 306 WP_071600497.1 hypothetical protein -
EL145_RS12040 2517736..2518068 + 333 WP_001349760.1 FlxA-like family protein -
EL145_RS12045 2518505..2519845 - 1341 WP_000589013.1 ISNCY family transposase -
EL145_RS12060 2520642..2521841 + 1200 WP_001117227.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2482426..2537759 55333


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287477 WP_000323025.1 NZ_LR134295:c2516964-2516677 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287477 WP_000534858.1 NZ_LR134295:c2517203-2516964 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References