Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1153472..1154134 Replicon chromosome
Accession NZ_LR134294
Organism Streptococcus pneumoniae strain NCTC12977

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL096_RS06060 Protein ID WP_172592534.1
Coordinates 1153961..1154134 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EL096_RS06055 Protein ID WP_000961810.1
Coordinates 1153472..1153924 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL096_RS06025 1148851..1149594 - 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
EL096_RS06030 1149596..1150546 - 951 WP_050072374.1 50S ribosomal protein L11 methyltransferase -
EL096_RS06035 1150682..1151198 - 517 Protein_1155 GNAT family N-acetyltransferase -
EL096_RS06040 1151195..1151623 - 429 WP_050072375.1 NUDIX hydrolase -
EL096_RS06045 1151625..1152692 - 1068 WP_000719721.1 M50 family metallopeptidase -
EL096_RS06050 1152711..1153181 - 471 WP_054387465.1 DUF3013 family protein -
EL096_RS06055 1153472..1153924 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL096_RS06060 1153961..1154134 - 174 WP_172592534.1 type II toxin-antitoxin system HicA family toxin Toxin
EL096_RS06065 1154277..1154456 - 180 WP_001809903.1 hypothetical protein -
EL096_RS06075 1154621..1154860 - 240 WP_000818078.1 hypothetical protein -
EL096_RS06085 1155130..1156401 + 1272 WP_054387466.1 replication-associated recombination protein A -
EL096_RS06095 1156946..1158265 - 1320 WP_000502560.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6396.53 Da        Isoelectric Point: 10.8214

>T287465 WP_172592534.1 NZ_LR134294:c1154134-1153961 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQVGL

Download         Length: 174 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT287465 WP_000961810.1 NZ_LR134294:c1153924-1153472 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References