Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 658792..659290 Replicon chromosome
Accession NZ_LR134294
Organism Streptococcus pneumoniae strain NCTC12977

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EL096_RS03420 Protein ID WP_001812387.1
Coordinates 658792..659046 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EL096_RS03425 Protein ID WP_000208080.1
Coordinates 659048..659290 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL096_RS03405 654061..656529 - 2469 WP_001152989.1 DNA gyrase subunit A -
EL096_RS03410 656723..657709 + 987 WP_000204727.1 L-lactate dehydrogenase -
EL096_RS03415 657972..658745 - 774 WP_044811410.1 ion transporter -
EL096_RS03420 658792..659046 - 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL096_RS03425 659048..659290 - 243 WP_000208080.1 hypothetical protein Antitoxin
EL096_RS03430 659381..660190 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EL096_RS03435 660192..661541 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EL096_RS03440 661534..662238 - 705 WP_000722076.1 response regulator transcription factor -
EL096_RS03445 662293..663468 - 1176 WP_000886125.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.85 Da        Isoelectric Point: 10.7632

>T287464 WP_001812387.1 NZ_LR134294:c659046-658792 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT287464 WP_000208080.1 NZ_LR134294:c659290-659048 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References