Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 492977..494214 Replicon chromosome
Accession NZ_LR134294
Organism Streptococcus pneumoniae strain NCTC12977

Toxin (Protein)


Gene name pezT Uniprot ID A0A237K019
Locus tag EL096_RS02650 Protein ID WP_054387416.1
Coordinates 493453..494214 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID B6ZCC4
Locus tag EL096_RS02645 Protein ID WP_000579612.1
Coordinates 492977..493453 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL096_RS02615 488320..488508 + 189 WP_000179769.1 hypothetical protein -
EL096_RS02620 488570..489385 + 816 WP_050221225.1 ATP-grasp domain-containing protein -
EL096_RS02625 489385..490239 + 855 WP_000900015.1 ADP-ribosylglycohydrolase family protein -
EL096_RS02630 490351..491235 + 885 WP_050221224.1 diacylglycerol kinase family lipid kinase -
EL096_RS02635 491397..492101 + 705 WP_001865184.1 alpha amylase N-terminal ig-like domain-containing protein -
EL096_RS02640 492077..492532 + 456 WP_001865186.1 hypothetical protein -
EL096_RS02645 492977..493453 + 477 WP_000579612.1 helix-turn-helix domain-containing protein Antitoxin
EL096_RS02650 493453..494214 + 762 WP_054387416.1 zeta toxin family protein Toxin
EL096_RS02655 494242..495018 + 777 Protein_501 hypothetical protein -
EL096_RS02660 494946..495398 + 453 WP_078375108.1 hypothetical protein -
EL096_RS02665 496217..496576 + 360 WP_000003750.1 hypothetical protein -
EL096_RS02670 496586..496951 + 366 WP_000263054.1 MobC family plasmid mobilization relaxosome protein -
EL096_RS02675 496938..498788 + 1851 WP_054387417.1 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 470175..592032 121857


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29081.03 Da        Isoelectric Point: 6.5050

>T287463 WP_054387416.1 NZ_LR134294:493453-494214 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Download         Length: 762 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18245.68 Da        Isoelectric Point: 4.4188

>AT287463 WP_000579612.1 NZ_LR134294:492977-493453 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A237K019

Antitoxin

Source ID Structure
AlphaFold DB B6ZCC4

References