Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 2058188..2058745 Replicon chromosome
Accession NZ_LR134293
Organism Streptococcus canis strain NCTC12191

Toxin (Protein)


Gene name relE Uniprot ID G5KI09
Locus tag EL097_RS10370 Protein ID WP_003047235.1
Coordinates 2058473..2058745 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G5KI08
Locus tag EL097_RS10365 Protein ID WP_001140275.1
Coordinates 2058188..2058469 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL097_RS10335 2053541..2053990 - 450 WP_003047243.1 DUF4314 domain-containing protein -
EL097_RS10340 2053992..2054243 - 252 WP_003047241.1 hypothetical protein -
EL097_RS10345 2054418..2055596 - 1179 WP_003047239.1 DNA (cytosine-5-)-methyltransferase -
EL097_RS10350 2055593..2056183 - 591 WP_000073292.1 HNH endonuclease -
EL097_RS10355 2056183..2057436 - 1254 WP_006740451.1 DNA modification methylase -
EL097_RS10360 2057408..2057863 - 456 WP_000999415.1 hypothetical protein -
EL097_RS10365 2058188..2058469 + 282 WP_001140275.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL097_RS10370 2058473..2058745 + 273 WP_003047235.1 type II toxin-antitoxin system YafQ family toxin Toxin
EL097_RS10375 2058788..2059147 - 360 WP_001138026.1 HNH endonuclease -
EL097_RS10380 2059149..2059889 - 741 WP_003047233.1 methionine adenosyltransferase domain-containing protein -
EL097_RS10385 2060293..2060790 - 498 WP_006738435.1 hypothetical protein -
EL097_RS10390 2060783..2062159 - 1377 WP_000773770.1 DEAD/DEAH box helicase -
EL097_RS10395 2062140..2062421 - 282 WP_001208489.1 VRR-NUC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2030576..2069373 38797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-90)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10433.06 Da        Isoelectric Point: 8.9949

>T287462 WP_003047235.1 NZ_LR134293:2058473-2058745 [Streptococcus canis]
MLQLVTTNQFRKDVKRAKKRGLNLKKLEAVLDPLQKEETLDEKHRDHALVGNYMGFRECHIEPDWLLVYAIDKGQLILTA
SRTGSHSDLF

Download         Length: 273 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10323.68 Da        Isoelectric Point: 4.4155

>AT287462 WP_001140275.1 NZ_LR134293:2058188-2058469 [Streptococcus canis]
MAKTANINLRIEPSTKAQAESLFGSFGISVTDAINIFLNTSIMEGGFPFQIKQPRYNRETELAMEEARQIMEGKVTTKSY
ASVSDLMADLNED

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829ID91

References