Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1615516..1616768 Replicon chromosome
Accession NZ_LR134293
Organism Streptococcus canis strain NCTC12191

Toxin (Protein)


Gene name sezT Uniprot ID A0A4V6LFA6
Locus tag EL097_RS08190 Protein ID WP_003048438.1
Coordinates 1615516..1616292 (-) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag EL097_RS08195 Protein ID WP_129545018.1
Coordinates 1616292..1616768 (-) Length 159 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL097_RS08180 1611646..1613463 - 1818 WP_003048440.1 ATP-dependent helicase -
EL097_RS08185 1613450..1615519 - 2070 WP_003048439.1 AAA family ATPase -
EL097_RS08190 1615516..1616292 - 777 WP_003048438.1 zeta toxin family protein Toxin
EL097_RS08195 1616292..1616768 - 477 WP_129545018.1 helix-turn-helix domain-containing protein Antitoxin
EL097_RS08200 1616838..1617128 - 291 WP_003048436.1 hypothetical protein -
EL097_RS08205 1617177..1617566 - 390 WP_003048435.1 hypothetical protein -
EL097_RS08210 1617563..1617790 - 228 WP_003048434.1 hypothetical protein -
EL097_RS08215 1617842..1618918 - 1077 WP_003048433.1 toprim domain-containing protein -
EL097_RS08220 1618958..1619596 - 639 WP_003048431.1 hypothetical protein -
EL097_RS08225 1619691..1619990 - 300 WP_003048429.1 hypothetical protein -
EL097_RS08230 1620001..1620300 - 300 WP_003048427.1 hypothetical protein -
EL097_RS08235 1620371..1621180 - 810 WP_003048426.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1533694..1666960 133266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(26-215)

Antitoxin

(3-60)


Sequences


Toxin        


Download         Length: 259 a.a.        Molecular weight: 29167.06 Da        Isoelectric Point: 5.4479

>T287461 WP_003048438.1 NZ_LR134293:c1616292-1615516 [Streptococcus canis]
MRLEEFSEAAFQKALQRTIRALTREKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRKTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQECLFGKWIKVEEEML
KVGQEQLCELVSGNGDKK

Download         Length: 777 bp


Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18240.69 Da        Isoelectric Point: 4.6565

>AT287461 WP_129545018.1 NZ_LR134293:c1616768-1616292 [Streptococcus canis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDHQLTLKVE
VIKERGAAILSKLYRYQDGQDIAFDDESNPWILMSDDLAELLHTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4V6LFA6


Antitoxin

Source ID Structure

References